How can communities around the world prepare for, detect, and respond to emerging pandemics and health security threats?

Over $1.5 million in prize funding is available for Solve's 2020 Global Challenges, including Health Security & Pandemics.




Coronavirus disease 2019 (Covid-19) is the latest in a series of infectious disease emergencies, including cholera, Ebola, SARS, Chikungunya, HIV/AIDS, and influenza. While scientists and drug developers, with support f...

How can communities around the world prepare for, detect, and respond to emerging pandemics and health security threats?

Over $1.5 million in prize funding is available for Solve's 2020 Global Challenges, including Health Security & Pandemics.




Coronavirus disease 2019 (Covid-19) is the latest in a series of infectious disease emergencies, including cholera, Ebola, SARS, Chikungunya, HIV/AIDS, and influenza. While scientists and drug developers, with support f...

Health officials in the U.K. are warning that Covid-19 could be causing a new and rare inflammatory condition in children. Britain’s Paediatric Intensive Care Society said Monday the National Health Service alerted it to a small number of critically ill children resenting with “an unusual clinical picture.” The society noted that many — but not all — of the children with symptoms of the new inflammatory disease had been diagnosed with Covid-19. The condition was likened to toxic shock syn...

Their goal is to provide useful information to clinicians about helmet use for noninvasive ventilation in patients who have respiratory distress as a complication of the COVID-19 virus. Helmet-based ventilation saves lives, shortens ICU stays for patients who need mechanical ventilation and can be used on step-down units. In addition, it can be used for other patients who have different causes of respiratory distress.

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We report five cases of large-vessel stroke in patients younger than 50 years of age who presented to our health system in New York City. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed in all five patients.

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The ongoing COVID-19 outbreak has spread rapidly on a global scale. While the transmission of SARS-CoV-2 via human respiratory droplets and direct contact is clear, the potential for aerosol transmission is poorly understood1–3. This study investigated the aerodynamic nature of SARS-CoV-2 by measuring viral RNA in aerosols in different areas of two Wuhan hospitals during the COVID-19 outbreak in February and March 2020. The concentration of SARS-CoV-2 RNA in aerosols detected in isolation...

The coronavirus disease 2019 (COVID-19) pandemic is raising levels of anxiety worldwide: both appropriate anxiety in reaction to real dangers and maladaptive panic. Beyond handwashing, a key public health directive is social distancing, which entails avoiding public gatherings and generally keeping physical distance from others. The economy is shutting down, leaving people at home without the structure of their daily work routine. The closing of theatres, museums, restaurants, and bars ha...

Eight ways in which scientists hope to provide immunity to SARS-CoV-2. 
More than 90 vaccines are being developed against SARS-CoV-2 by research teams in companies and universities across the world. Researchers are trialling different technologies, some of which haven’t been used in a licensed vaccine before. At least six groups have already begun injecting formulations into volunteers in safety trials; others have started testing in animals. Nature’s graphical guide explains each vaccine ...

The rapidly evolving and progressing nature of the present COVID-19 pandemic has highlighted several critical limitations in the traditional model of surgical research; namely, the inability to provide timely evidence to rapidly inform and change clinical practice, thus ultimately defeating its main purpose of improving patient outcomes. The key question remains the same; ‘how do we deliver the best possible care for our patients?’ What has changed however is that the novel context of a r...

Introduction

As COVID-19 infections soar worldwide, surgical teams must quickly adapt to care for the COVID-19-positive patient in the operating room (OR). This challenge comes in the face of constant change in data and conditions, reliable evidence yet to emerge, shortages of personal protective equipment (PPE), uncertainty due to lack of testing equipment and capacity, and unprecedented strain on caregivers, hospital systems, and resources.



Agility is essential not...

Amidst the SARS-CoV-2 or “COVID-19” pandemic, the need for trauma care remains a critical public health responsibility. Anticipating augmentation of social determinants of violence, “end stage” presentations of surgical pathologies from delayed care, and demands on surgeons and surgical intensivists, readiness, adaptability, and leadership in trauma centers are paramount. This Surgical Perspectives centers around an urban, Level-1 trauma center’s experience in meeting the challenge to mai...

In the setting of the novel COVID-19 pandemic, prehabilitation may support cancer patients who are receiving neoadjuvant therapy prior to anticipated surgery. Recommended “social distancing” among these immunocompromised patients may decrease their physical activity and increase the risk of cardiopulmonary deconditioning and sarcopenia, in addition to the psychosocial stress of a cancer diagnosis, predicted future surgery, and community withdrawal. The resultant cascade of physiologic and...