The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) has revised its guidance so that pregnant and breastfeeding women can receive the covid-19 vaccine.
Writing in BMJ Opinion, Helen Hare, an acute medicine trainee, and Kate Womersley, an academic foundation trainee, said that the change had come after strong pressure from campaigners, clinicians, and some of the women affected.1
The MHRA had previously recommended that breastfeeding women should not be g...
Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients28 Dec, 2020AbstractBackground
COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is a master transcription factor involved in the cellular response to oxygen levels. The immunopathogenesis of this severe form of COVID-19 is poorly understood.
We performed scRNAseq from leukocytes from five critically ill COVID-19 patients and characterized the expression of hypoxia-inducibl...
There is evidence the new variant could be more transmissible, yet vaccines work very well against it
A new mutated form of the novel coronavirus that appears more transmissible than the original has raised alarm in the U.K. and around the world. It does not appear to cause more severe disease, and the newly available vaccines do seem to protect people against it. Yet on December 19—after an announcement that the variant, dubbed B.1.1.7, had suddenly accumulated 17mutations and was spreadi...0
IgG antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anti-cancer therapeutic antibodies for their elevated activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (~6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other...0
The test could prove useful for large-scale screening and epidemiological surveys and cuts down on reliance on blood draws
A new saliva-based test developed by a team at Johns Hopkins Bloomberg School of Public Health has been found to accurately detect the presence of antibodies to SARS-CoV-2, the virus that causes COVID-19, from small samples of saliva. Such tests, the results of which can be obtained in a matter of hours, are seen as potential alternatives to blood-sampl...
The science supports that face coverings are saving lives during the coronavirus pandemic, and yet the debate trundles on. How much evidence is enough?
When her Danish colleagues first suggested distributing protective cloth face masks to people in Guinea-Bissau to stem the spread of the coronavirus, Christine Benn wasn’t so sure.
“I said, ‘Yeah, that might be good, but there’s limited data on whether face masks are actually effective,’” says Benn, a global-health resear...
We're now more than seven months into the coronavirus pandemic that has upended the lives of most of Earth's inhabitants. And while it is true that the scientific community has learned many things about the SARS-CoV-2 virus and the disease it causes, Covid-19, there are also many gaps in our understanding.
One big mystery: Why do some people get very sick and even die from their illness, while other similar people show no symptoms and may not realize they've been infected at all?We kno...
Edición genética con CRISPR y estudios de serovigilancia, nuevos informes del Grupo ISCIII de Análisis sobre Coronavirus
El Grupo de Análisis Científico sobre Coronavirus del ISCIII ha publicado dos nuevos informes, sobre los posibles usos de la tecnología CRISPR de edición genética y sobre el desarrollo de estudios de serovigilancia epidemiológica, que como en casos anteriores incluyen un resumen divulgativo y un texto completo de carác...
The COVID-19 pandemic has drastically accelerated the need for the advancement of healthcare’s digital transformation. The obligation to stay at home caused by the pandemic has sped up the transition from to face-to-face work to remote work through the use of digital technologies and web resources.
Reliance on technology has negatively affected human attention, decision-making capacity, and emotional wellbeing - added to increased tension and lack of concentration. 31% of primary c...
As lockdowns ease, thermal imaging cameras are popping up in all sorts of public places to assess the state of people's health. In this report you will find some tips regarding thermal imaging cameras.
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The following is a brief roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.
Convalescent plasma disappoints in Chinese trial
Hydroxychloroquine fails to protect against infection in key trial
Timing, location of sample may impact coronavirus test results
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Questions raised over study claiming drug linked to higher rate of mortality and heart problems in Covid-19 patients
The World Health Organization will resume clinical trials of an anti-malaria drug researchers hope may treat Covid-19, after a study of the drug published in May by a major medical journal prompted them to halt trials due to safety concerns.
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