The scientific community worldwide has mobilized with unprecedented speed to tackle the COVID-19 pandemic, and the emerging research output is staggering. Every day, hundreds of scientific papers about COVID-19 come out, in both traditional journals and non-peer-reviewed preprints. There’s already far more than any human could possibly keep up with, and more research is constantly emerging.
And it’s not just new research. We estimate that there are as many as 500,000 papers relevant to COV...

The U.S. Food and Drug Administration has issued the first emergency use authorization (EUA) for a COVID-19 antigen test, a new category of tests for use in the ongoing pandemic. These diagnostic tests quickly detect fragments of proteins found on or within the virus by testing samples collected from the nasal cavity using swabs. The EUA was issued late Friday to Quidel Corporation for the Sofia 2 SARS Antigen FIA. This test is authorized for use in high and moderate complexity lab...

There is growing consensus among modelers estimating the number of cases and deaths from the novel coronavirus in the next few weeks.

But this convergence of estimates — 31,000 to 42,000 additional deaths through mid-June for roughly 120,000 total deaths in the United States — comes just as shifts in public policy are likely to create new uncertainty about the path of the pandemic after that.

Three weeks ago, predictions from five popular models were widely divergent. Now, t...

The Chinese city of Wuhan will begin what it is calling "10 days of mass battle" to test all 11 million residents after the discovery of a new cluster of coronavirus cases, NPR's Emily Feng reported.

Each of the city's districts will be required to create a testing plan by Tuesday, according Reuters, which first reported the initiative.

Wuhan, where the world's first coronavirus cases were reported in late December, eased many restrictions in early April after a strict lockd...

Coronavirus disease 2019 (COVID-19) has been shown to affect different parts of the body, and ophthalmological changes have been associated with ocular external diseases such as conjunctivitis.
Optical coherence tomography (OCT) is a non-invasive imaging technique that is useful for demonstrating subclinical retinal changes in systemic conditions such as diabetes, Parkinson's disease, and Alzheimer's disease, as well as many viral infections. We used OCT to evaluate patients infected by se...

The prevalence and prognosis of digestive system involvement, including gastrointestinal symptoms and liver injury, in patients with COVID-19 remains largely unknown. We aimed to quantify the effects of COVID-19 on the digestive system.
In this systematic review and meta-analysis, we systematically searched PubMed, Embase, and Web of Science for studies published between Jan 1, 2020, and April 4, 2020. The websites of WHO, CDC, and major journals were also searched. We included studies t...

At least eight candidates for a coronavirus vaccine are in the clinical development stage, and some could be ready as early as the “late fall”, Anthony Fauci, the US’ top infectious disease expert, has told senators.
“The [National Institutes of Health] has been collaborating with a number of pharmaceutical companies at various stages of development,” Mr Fauci said, in testimony on Tuesday.


As part of that plan, the administration is moving ahead with production of the vaccines ...

Gains made in preventing mother-to-child transmission of HIV could be reversed, with new HIV infections among children up by as much as 104%
A modelling group convened by the World Health Organization and UNAIDS has estimated that if efforts are not made to mitigate and overcome interruptions in health services and supplies during the COVID-19 pandemic, a six-month disruption of antiretroviral therapy could lead to more than 500 000 extra deaths from AIDS-related illnesses, including from ...

The COVID-19 pandemic has brought unprecedented challenges regarding the ability to generate timely evidence, even as the disease overwhelms health care systems and stresses the clinical workforce. This SSC guideline will be frequently updated online as global evidence accrues, but it reflects the central tenants of best practices for ARDS: low tidal volume strategy, PEEP titration, avoidance of hyperoxia, and a conservative fluid strategy.

This is the first edition of guidance on infection prevention and control (IPC) strategies for use when COVID-19 is suspected. It has been adapted from WHO’s Infection prevention and control during health care for probable or confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, based on current knowledge of the situation and experience with severe acute respiratory syndrome (SARS) and MERS. WHO will update these recommendations as new information becomes a...

Joint Statement: Roadmap for Resuming Elective Surgery after COVID-19 PandemicAmerican College of Surgeons American Society of Anesthesiologists Association of periOperative Registered Nurses American Hospital Association
Introduction In response to the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC), the U.S. Surgeon General and many medical specialties such as the American College of Surgeons and the American Society of Anesthesiologists recommended interim ca...

In order to focus local resources on managing the new coronavirus (COVID-19) pandemic, “elective” surgery has been largely postponed and stopped. As the COVID-19 rates have already reached their peaks, or will do so over the next week or two (depending on location), the current focus for an increasing number of facilities is toward “ramping up” to prepare for elective operations.

The current document offers a set of principles and issues to help local facilities plan for resumption...