6 strategies for teens facing a new (temporary) normal.



Being a teenager is difficult no matter what, and the coronavirus disease (COVID-19) is making it even harder. With school closures and cancelled events, many teens are missing out on some of the biggest moments of their young lives — as well as everyday moments like chatting with friends and participating in class.

For teenagers facing life changes due to the outbreak who are feeling anxious, isolated and disap...

AbstractIn the case that O-glycosylation plays a key role in the pathogenesis of coronavirus disease, as was discussed in a previous SARS-CoV infection and is predicted for the current SARS-CoV-2 or COVID-19, this would involve the formation of hybrid, serologically A-like, O-N-acetyl-d-galactosamine (GalNAc)α1-Ser/Thr-R, Tn (“T nouvelle”) structures. Although the angiotensin-converting-enzyme 2 (ACE2) protein, mediating the transferring enzymes, is defined as the primary SARSCoV receptor,...

Background The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. Currently, neutralizing antibodies (NAbs) versus this virus are expected to correlate with recovery and protection of this disease. However, the characteristics of these antibodies have not been well studied in association with the clinical manifestations in patients. Methods Plasma collected from 175 COVID-19 recovered patients with mild symptoms were screened using a safe and sensitive pseudoty...

An outbreak of the Corona Virus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome CoV-2 (SARS-CoV-2), began in Wuhan and spread globally. Recently, it has been reported that discharged patients in China and elsewhere were testing positive after recovering. However, it remains unclear whether the convalescing patients have a risk of “relapse” or “reinfection”. The longitudinal tracking of re-exposure after the disappeared symptoms of the SARS-CoV-2-infected monkeys was p...

Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities, however, remain incompletely understood.
SARS-CoV-2 infects the host using the angiotensin converting enzyme 2 (ACE2) receptor, which is expressed in several organs, including th...

Scott Morrison says consent will be key, indicating the app won’t be mandatory, but it could play a part in easing Covid-19 restrictions. 



The Australian government is planning to launch an app in a matter of weeks that will trace every person who has been in contact with a mobile phone owner who has tested positive for coronavirus in the previous few weeks, in a bid to automate coronavirus contact tracing, and allow the easing of restrictions. Here’s what we know about the...

Germany gave the green light for human trials of potential coronavirus vaccines developed by German biotech company BioNTech, which is racing teams in Germany, the U.S. and China to develop an agent that will stop the pandemic.

The trial, only the fourth worldwide of a vaccine targeting the virus, will be initially conducted on 200 healthy people, with more subjects, including some at higher risk from the disease, to be included in a second stage, German vaccines regulator the Paul...

One important characteristic of viruses and other pathogens is how contagious they are. This is measured in a few ways. One key measure is the R0, or basic reproduction number, which indicates how many new cases one infected person generates. For an R0 of three we would expect each new case of a disease to produce three other infections. This is not just a measure of the inherent infectiousness of a disease. It also depends on other factors, including the rate of contact within a population a...

Studies of past outbreaks reveal a toll on health care workers. During the severe acute respiratory syndrome (SARS) epidemic of 2003, 89% of 271 health care workers in Hong Kong reported negative psychological effects, including exhaustion and fear of social contact. And for up to 2 years after the epidemic dwindled, health care workers in Toronto, another city hit hard by SARS, had significantly higher than normal levels of burnout, psychological distress, and post-traumatic stress.
Those...

Studies from serum samples could transform our understanding of the spread of COVID-19, but what antibodies alone say about immunity is not yet clear.
It’s months into the coronavirus pandemic and public health officials still don’t know how many people have actually contracted the culprit, SARS-CoV-2. In many countries testing capacity has lagged behind the spread of the virus. Large numbers of people have developed COVID-19 symptoms but have not been tested, and the vast majority of peop...

Serologic testing helped scientists establish connections between two people with COVID-19 from Wuhan, China, to three clusters in Singapore, according to a study yesterday in The Lancet Infectious Diseases.




Also, a study today in The Journal of Infectious Diseases found that four of eight COVID-19 cases in three family clusters in China were asymptomatic or had only mild symptoms.




In a related study out of China in the same journal, researchers descr...

Abstract BackgroundEffective therapeutics to treat COVID-19 are urgently needed. Remdesivir is a nucleotide prodrug with in vitro and in vivo efficacy against coronaviruses. Here, we tested the efficacy of remdesivir treatment in a rhesus macaque model of SARS-CoV-2 infection.
MethodsTo evaluate the effect of remdesivir treatment on SARS-CoV-2 disease outcome, we used the recently established rhesus macaque model of SARS-CoV-2 infection that results in transient lower respiratory tract...