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  • Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial

    2 Feb, 2021
    BackgroundTo mitigate the effects of COVID-19, a vaccine is urgently needed. BBV152 is a whole-virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG) or alum (Algel).MethodsWe did a double-blind, multicentre, randomised, controlled phase 1 trial to assess the safety and immunogenicity of BBV152 at 11 hospitals across India. Healthy adults aged 18–55 years who were deemed healthy by the investigator were eligible. Individua...
  • Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

    2 Feb, 2021
    BackgroundPatients with COVID-19 pneumonia have an excess of inflammation and increased concentrations of cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients in hospital with mild-to-moderate COVID-19 pneumonia.MethodsIn this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within the CORIMUNO-19 cohort, we recruited patients from 16 University hos...
  • New variant of SARS-CoV-2 in UK causes surge of COVID-19

    11 Jan, 2021
    For most of November, 2020, England was in lockdown to force down the incidence of COVID-19 cases that had steadily increased in the late summer and autumn. Other countries in the UK (Wales, Scotland, and Northern Ireland) had also been reimposing and subsequently lifting restrictions, since each of the four nations is in charge of its own COVID-19 control plans.For a while, the strategy in England appeared to have worked, with many areas that previously had high case incidence seeing rates d...
  • Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data

    4 Jan, 2021
    Abstract The SARS-CoV-2 lineage B.1.1.7, now designated Variant of Concern 202012/01 (VOC) by Public Health England, originated in the UK in late Summer to early Autumn 2020. We examine epidemiological evidence for this VOC having a transmission advantage from several perspectives. First, whole genome sequence data collected from community-based diagnostic testing provides an indication of changing prevalence of different genetic variants through time. Phylodynamic modelling additio...
  • Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

    16 Dec, 2020
    SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus. It is, however, unknown which features of the serological response may affect clinical outcomes of COVID-19 patients. We analyzed 983 longitudinal plasma samples from 79 hospitalized COVID-19 patients and 175 SARS-CoV-2-infected outpatients and asymptomatic individuals. Within this c...
  • Digital Health Surveillance Strategies for Management of Coronavirus Disease 2019

    15 Dec, 2020
    To describe the design, implementation and utilization of Electronic Health Record (EHR) based digital health surveillance strategies used to manage the coronavirus disease (COVID-19) pandemic and ensure delivery of high quality clinical care such as case identification, remote monitoring, telemedicine services, and recruitment to clinical trials at Mayo Clinic.
    Mayo Clinic, a large multistate integrated health care system with over 1.5 million annual patien...
  • Simultaneous detection and differentiation of SARS-CoV-2, influenza A virus and influenza B virus by one-step quadruplex real-time RT-PCR in patients with clinical manifestations

    15 Dec, 2020
    AbstractObjectives:In order to develop a novel method based on the quadruplex assay which is a valuable diagnostic tool for the diagnosis of SARS-CoV-2 infection, differential diagnosis and detection of coinfections. Methods: A one-step quadruplex real-time reverse transcription-PCR (rRT-PCR) assay was developed for simultaneous detection and differenation of SARS-CoV-2 ORF1ab and N genes, influenza A virus (hIAV) and influenza B virus (hIBV).Results: The results showed tha...
  • Focus shifts to antibody cocktails for COVID-19 cytokine storm

    24 Nov, 2020
    Emerging clinical trial data suggest that individual immunomodulatory drugs can dampen the hyperactive immune system in severe COVID-19, but polytherapy is the way forward.
    On June 5 the Ministry of Health of the Russian Federation registered Biocad’s Ilsira (levilimab) as a treatment for severe COVID-19. Ilsira is one of several monoclonal antibodies (mAbs) targeting interleukin-6 receptor (IL-6R) and a host of other inflammatory cytokines currently in clinical testing against coronavirus...
  • Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

    24 Nov, 2020
    Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (...
  • Telemedicine Usage Among Urologists During the COVID-19 Pandemic: Cross-Sectional StudyTelemedicine Usage Among Urologists During the COVID-19 Pandemic: Cross-Sectional Study

    10 Nov, 2020
    Background: Prior to the COVID-19 pandemic, urology was one of the specialties with the lowest rates of telemedicine and videoconferencing use. Common barriers to the implementation of telemedicine included a lack of technological literacy, concerns with reimbursement, and resistance to changes in the workplace. In response to the COVID-19 pandemic declared in March 2020, the delivery of urological services globally has quickly shifted to telemedicine to account for the mass ...
  • Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis

    10 Nov, 2020
    Previous studies have indicated Coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate.
    We conducted a systematic review of studies that reported fatalities in COVID-19 patients with cancer. A comprehensive meta-analysis that assessed the overall case fatality rate and associated risk factors was performed. Using individual patient data, univariate and multivariate logistic regression analyses were used to estimate odds ratios (OR) for e...