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    Outreach and influence of surgical societies` recommendations on minimally invasive surgery during the COVID-19 pandemic – an anonymized international urologic expert inquiry

    16 Aug, 2020
    To assess the outreach and influence of the main recommendations of surgical governing bodies on adaptation of minimally invasive laparoscopic surgery (MIS) procedures during the COVID-19 pandemic in an anonymized multi-institutional survey.
    Materials and Methods
    International experts performing MIS were selected on the basis of the contact database of the speakers of the Friends of Israel Urology Symposium. A 24-item questionnaire was built using main recommend...
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    Development and validation of a surgical prioritization and ranking tool and navigation aid for head and neck cancer (SPARTAN‐HN) in a scarce resource setting: Response to the COVID‐19 pandemic

    16 Aug, 2020

    In the wake of the coronavirus disease 2019 (COVID‐19) pandemic, access to surgical care for patients with head and neck cancer (HNC) is limited and unpredictable. Determining which patients should be prioritized is inherently subjective and difficult to assess. The authors have proposed an algorithm to fairly and consistently triage patients and mitigate the risk of adverse outcomes.


    Two separate expert panels, a consensus panel (11 partici...
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    Mutational spectra of SARS‐CoV‐2 orf1ab polyprotein and signature mutations in the United States of America

    16 Aug, 2020
    AbstractPandemic COVID‐19 outbreak has been caused due to SARS‐CoV‐2 pathogen, resulting millions of infection and death worldwide, USA being on top at the present moment. The long, complex orf1ab polyproteins of SARS‐CoV‐2 play an important role in viral RNA synthesis. To assess the impact of mutations in this important domain, we analyzed 1134 complete protein sequences of orf1ab polyprotein from NCBI Virus database from affected patients across various states of USA from December 2019 to 2...
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    Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

    11 Aug, 2020
    COVID-19 represents a global crisis, yet major knowledge gaps remain about human immunity to SARS-CoV-2. We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta. In PBMCs of COVID-19 patients, there was reduced expression of HLA-DR and pro-inflammatory cytokines by myeloid cells, and impaired mTOR-signaling and IFN-α production by plasmacytoid DCs. In contrast, there were enhanced plasma levels of inflammatory mediators, including...
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    Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic

    11 Aug, 2020

    AbstractMany patients with ER+ HER2− primary breast cancer are being deferred from surgery to neoadjuvant endocrine therapy (NeoET) during the COVID-19 pandemic. We have collated data from multiple international trials of presurgical endocrine therapy in order to provide guidance on the identification of patients who may have insufficiently endocrine-sensitive tumors and should be prioritised for early surgery or neoadjuvant chemotherapy rather than NeoET during or in the aftermath of the...
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    Face Masks and Respirators in the Fight Against the COVID-19 Pandemic: A Review of Current Materials, Advances and Future Perspectives

    10 Aug, 2020


    The outbreak of COVID-19 has spread rapidly across the globe, greatly affecting how humans as a whole interact, work and go about their daily life. One of the key pieces of personal protective equipment (PPE) that is being utilised to return to the norm is the face mask or respirator. In this review we aim to examine face masks and respirators, looking at the current materials in use and possible future innovations that will enhance their protection against SARS-...
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    How to resume elective surgery in light of COVID-19 post-pandemic propofol shortage: The common concern of anaesthesists and surgeons

    10 Aug, 2020
    The coronavirus disease 2019 (COVID-19) pandemic has stressed health-system capacity and human resources and is about to decimate the pharmaceutical supply chain of injectable anaesthetic drugs, which has already been under severe strain for decades. As most countries are now emerging from their lockdowns, one of the main challenge is to reboot the entire healthcare system and the surgical care delivery in a detrimental context.
     For reading full text click the link.&nb...
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    A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19

    10 Aug, 2020


    To control the COVID-19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, a method for a rapid, simple, and inexpensive point-of-care diagnosis and mass screening is urgently needed. We developed and evaluated a one-step colorimetric reverse-transcriptional loop-mediated isothermal amplification assay (COVID-19-LAMP) for detection of SARS-CoV-2, using SARS-CoV-2 isolate and respiratory samples from patients with COVID-19 ...
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    Obesity and COVID-19: a call for action from people living with obesity

    7 Aug, 2020
    The Lancet publishes an article talking about how COVID-19 affects in obesity.Data from France and the UK have showed a disproportionately higher prevalence of obesity in patients with COVID-19 admitted to Intensive Care Units (ICUs) compared with general population data. About 10% of ICU patients in the UK have a BMI of 40 kg/m2 or more, and evidence shows increased mortality among this group. The UK Government advice for those with a BMI of at least 40 kg/m2 is to b...
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    SOFFCO-MM guidelines for the resumption of bariatric and metabolic surgery during and after the Covid-19 pandemic

    5 Aug, 2020

    Bariatric/metabolic surgery was paused during the Covid-19 pandemic. The impact of social confinement and the interruption of this surgery on the population with obesity has been underestimated, with weight gain and worsened comorbidities. Some candidates for this surgery are exposed to a high risk of mortality linked to the pandemic. Obesity and diabetes are two major risk factors for severe forms of Covid-19. The only currently effective treatment for obesity is metabolic surgery, which...
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    Therapeutic options for emergency gastrointestinal malignancy in COVID19 pandemic. The role of operative endoscopy

    4 Aug, 2020

    The concept that medical facilities and health workers might be an important contamination route in the pandemic has brought to consequences and attitudes for the population as well for legislators. In the pandemic period, most of the patients requiring intervention for gastrointestinal malignancy are in emergency, no‐deferrable conditions. We reviewed the results of operative endoscopy to treat emergencies secondary to gastrointestinal malignancy during the lock down period in Italy, fro...
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    Evidence‐based approach for surgery during COVID ‐19: Review of the literature and social media

    3 Aug, 2020
    The rapid global spread of COVID‐19 presents an unprecedented crisis for the surgical community. We aimed to identify specific and ongoing challenges in the surgical community by reviewing the current available literature on COVID‐19 and surgery and analysing the social media.
    The literature was reviewed following the PRISMA statement on PUBMED library, searched on May 23nd 2020, using “COVID‐19”, “COVID 19” with “surgery” syntax.

    Social media analysi...