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    Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

    18 Sep, 2020
    The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we report a humanized monoclonal antibody, H014, that efficiently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at nanomolar concentrations by engaging the spike (S) receptor binding domain (RBD). H0...
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    Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

    18 Sep, 2020
    An excessive immune response during coronavirus disease (COVID-19) can induce cytokine release syndrome (CRS), which is associated with life-threatening complications and disease progression. This retrospective study evaluated the clinical characteristics of severe CRS (sCRS, grade 3–4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). Grade 4 CRS was significantly more common in the COVID-19 group (15/40 (3...
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    Progress in the diagnosis and treatment of COVID-19 and the role of surgeons in the front line of the pandemic

    6 Sep, 2020
    The current struggle to control and contain COVID-19 is critical and surgeons are on the front line in the fight against this virus. Surgeons, and other medical workers in the field of surgery, have a solid foundation and experience in medical treatment and intensive care, and an understanding of the support of respiratory, circulatory, digestive, and other systemic organs. Furthermore, the operative standards of aseptic techniques in their daily work enable surgeons to adapt to the working e...
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    Is BMI Higher in Younger Patients with COVID‐19? Association Between BMI and COVID‐19 Hospitalization by Age

    4 Sep, 2020

    Obesity has been found to be a risk factor for hospitalization with coronavirus disease (COVID‐19). This study investigated whether patients hospitalized with COVID‐19 differed in BMI at older versus younger ages and whether trends were independent of diabetes and hypertension.


    A cross‐sectional analysis of patients hospitalized with moderate to severe COVID‐19 at Northwestern Memorial Hospital from March 19, 2020, until April 4, 2020, was pe...
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    Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic

    4 Sep, 2020
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global pandemic. It is hypothesized that the virus spreads from person to person via respiratory droplets or contact with contaminated surfaces and objects. Prior studies evaluating environmental contamination with SARS-CoV-2 have been conducted in health care settings treating patients known to have coronavirus disease 2019 (COVID-19); however, studies evaluating clinics that do not ...
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    Heart Failure In Covid‐19 Patients: Prevalence, Incidence And Prognostic Implications

    4 Sep, 2020

    Data regarding impact of COVID‐19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) is lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with confirmed COVID‐19 infection and prior diagnosis of HF. Also, to identify predictors and prognostic implications for AHF decompensations during hospital admission and to determine whether there was a correlation between withdr...
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    The impact of coronavirus disease 2019 on the practice of thoracic oncology surgery: a survey of members of the European Society of Thoracic Surgeons (ESTS)

    1 Sep, 2020
    There is widespread acknowledgment that coronavirus disease 2019 (COVID-19) has disrupted surgical services. The European Society of Thoracic Surgeons (ESTS) sent out a survey to assess what impact the COVID-19 pandemic has had on the practice of thoracic oncology surgery.
    All ESTS members were invited (13–20 April 2020) to complete an online questionnaire of 26 questions, designed by the ESTS learning affairs committee.
    The response rate was 23.0% an...
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    Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine

    1 Sep, 2020
    Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Nevertheless, currently, no proven effective therapies for this virus exists. The vaccines are deemed as a significant part of disease prevention for emerging viral diseases, since, in se...
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    Facial Trauma Management during the COVID-19 era: a primer for surgeons

    30 Aug, 2020
    Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has caused more than 6.1 million confirmed cases of COVID-19 in more than 188 countries, and has caused more than 370,000 deaths globally as of June 1, 2020. In addition, thousands of healthcare workers have also got infected with the virus. COVID-19 patients release large amounts of infectious viral particles in form of droplets from cough, sneeze and respiratory secretions....
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    Immunogenicity of a single-dose compared with a two-dose primary series followed by a booster dose of ten-valent or 13-valent pneumococcal conjugate vaccine in South African children: an open-label, randomised, non-inferiority trial

    30 Aug, 2020
    BackgroundRoutine childhood immunisation with pneumococcal conjugate vaccine (PCV) has changed the epidemiology of pneumococcal disease across age groups, providing an opportunity to reconsider PCV dosing schedules. We aimed to evaluate the post-booster dose immunogenicity of ten-valent (PCV10) and 13-valent (PCV13) PCVs between infants randomly assigned to receive a single-dose compared with a two-dose primary series.MethodsWe did an open-label, non-inferiority, randomised study in HIV-unexp...
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    A prospective cohort study of the impact of covid19 world pandemic on the management of emergency surgical pathology

    28 Aug, 2020
    The global pandemic due to the SARS‐Cov‐2 virus is having an unprecedented impact on surgical procedures1. Despite having started multiple analyzes on surgery during the pandemic2, there have been no studies on the impact of its on the management of emergency surgical pathology. Thus, a comparative cohort study of prospective databases was done. Study group (n = 127) included emergency surgeries done during COVID‐19 pandemic: between March 11, 2020 (declaration of a global...
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    The potential public health consequences of COVID-19 on malaria in Africa

    28 Aug, 2020
    The burden of malaria is heavily concentrated in sub-Saharan Africa (SSA) where cases and deaths associated with COVID-19 are rising1. In response, countries are implementing societal measures aimed at curtailing transmission of SARS-CoV-22,3. Despite these measures, the COVID-19 epidemic could still result in millions of deaths as local health facilities become overwhelmed4. Advances in malaria control this century have been largely due to distribution of long-lasting insecticida...