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    Remdesivir for severe covid-19: a clinical practice guideline

    26 Aug, 2020
    Clinical question What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.

    Current practice Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. After rapid market approval in the US, remdesivir is already being used in clinical practice.

    Recommendations The guideline pan...
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    Elective Surgical Procedure Guidance

    25 Aug, 2020
    Current Status
    During the COVID-19 pandemic, surgeries and procedures (collectively referred to as “procedures”) for life-threatening conditions or those with a potential to cause permanent disability have been and continue to be allowed.

    Due to the COVID-19 pandemic, hospitals and ambulatory surgical treatment centers (ASTCs) have deferred nonessential procedures to conserve resources for the care of COVID-19 patients. Some procedures that could reasonably be delayed for a time hav...
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    Construction of a simple quality appraisal tool for rapid review of laparoscopic surgery guidelines during COVID‐19 pandemic

    24 Aug, 2020


    The theoretical danger of virus transmission during Laparoscopic Surgery (LS) via surgical smoke and laparoscopy gas prompted several academic/ national associations to issue many rapidly emerging guidelines for laparoscopic during COVID‐19 pandemic. Conventional appraisal tools like GRADE and AGREE II, which assess the quality of evidence and methodological rigor in the development of guidelines, have very rigorous exhaustive checklists. This makes them impractica...
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    What the immune response to the coronavirus says about the prospects for a vaccine

    24 Aug, 2020

    In the late 1980s, 15 healthy people moved into new apartments in Salisbury, UK. On their third day, each was asked to snort a nostrilful of solution containing a coronavirus — one of several viruses that causes the common cold. Then the volunteers spent three weeks quarantined at the Common Cold Unit, part of the Medical Research Council, where researchers monitored a range of symptoms. Some study participants likened stays at the Common Cold Unit to a vacation — if so, it was a holiday ...
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    ESSKA guidelines and recommendations for resuming elective surgery

    24 Aug, 2020
    The roadmap to elective surgery resumption after this COVID-19 pandemic should be progressive and cautious. The aim of this paper was to give recommendations and guidelines for resuming elective orthopedic surgery in the safest environment possible. Elective surgery should be performed in COVID-free facilities and hospital stay should be as short as possible. For matters of safety, patients considered first for surgery should be carefully selected according to COVID infection stat...
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    The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

    19 Aug, 2020
    Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reducti...
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    The conundrum of interleukin-6 blockade in COVID-19

    19 Aug, 2020
    Since the very first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were identified in China, patients with severe manifestations of COVID-19 have been shown to develop a hyperinflammatory syndrome resembling that seen in patients with either macrophage-activation syndrome or cytokine-release syndrome associated with chimeric antigen receptor T-cell therapy. As a result, in the absence of a specific antiviral treatment for SARS-CoV-2 infection, many thera...
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    Effect of COVID-19 on Surgical Training Across the United States: A National Survey of General Surgery Residents

    18 Aug, 2020
    COVID-19 emerged as a global pandemic in 2020 and has affected millions of lives. Surgical training has also been significantly affected by this pandemic, but the exact effect remains unknown. We sought to perform a national survey of general surgery residents in the United States to assess the effect of COVID-19 on surgical resident training, education, and burnout.
    An anonymous online survey was created and distributed to general surgery residents across the Un...
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    Anti‐SARS‐CoV‐2 Spike Antibodies are Stable in Convalescent Plasma when Stored at 4° Celsius for at Least 6 Weeks

    18 Aug, 2020
    As nations around the world continue to address the public health crisis of Coronavirus Disease 2019 (COVID19), the global medical and scientific communities continue to search for and develop therapeutic strategies for patients. To date, remdesivir presents one such option and can shorten the duration of hospitalization in patients with severe disease. Convalescent plasma (CP) has presented another option, with its use and safety supported by numerous case series and...
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    Joint Statement: Roadmap for Maintaining Essential Surgery during COVID-19 Pandemic

    18 Aug, 2020
    In response to the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC), the U.S. Surgeon General and many medical specialties such as the American College of Surgeons and the American Society of Anesthesiologists recommended interim cancelation of elective surgical procedures. Physicians and health care organizations responded appropriately and canceled non-essential cases across the country. Many patients have had their needed surgeries postponed due to th...
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    Worldwide Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: An International Survey

    16 Aug, 2020
    AbstractBackground and Aims
    Persons with inflammatory bowel disease (IBD) may be particularly vulnerable to COVID-19 either because of their underlying disease or its management. Guidance has been presented on the management of persons with IBD in the time of this pandemic by different groups. We aimed to determine how gastroenterologists around the world were approaching the management of IBD.
    Members of the World Gastroenterology Organization (WGO) IBD Task Force contacted ...
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    What is the Preferred Screening Tool for COVID-19 in Asymptomatic Patients Undergoing a Surgical or Diagnostic Procedure?

    16 Aug, 2020
    INTRODUCTION: Since the outbreak of COVID-19, measures were taken to protect healthcare staff from infection, to prevent infection of patients admitted to the hospital and to distribute PPE according to need. To assure the proper protection without overuse of limited supply of these equipments, screening of patients before surgical or diagnostic procedure was implemented. This study evaluates the results of this screening. METHOD: All patients screened for COVID-19 before procedure warra...