Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of pandemic outbreak, the number of patients can exceed maximum capacity of intensive care units (ICUs), and, thus, these individuals often receive non-invasive ventilation outside of the ICU. Effective treatments for this population are needed urgently. Anakinra is a recombinant interleukin-1 receptor antagonist that might be beneficial i...

Research could change standard of care protocols to prevent clotting associated with coronavirus.

Treating hospitalized COVID-19 patients with anticoagulants -- blood thinners that slow down clotting -- may improve their chances of survival, researchers from the Mount Sinai COVID Informatics Center report. The study, published in the May 6 issue of the Journal of the American College of Cardiology, could provide new insight on how to treat and manage coronavirus patients once ...

Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use.
METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center in New York City. Data were obtained regarding consecutive patients hospitalized with Covid-19, excluding those who were intubated, died, or discharged within 24 hours after presentation to the emergency department (study baseline). The primary end po...

AbstractThe rapid spread of the COVID‐19 pandemic created unprecedented challenges for the medical and surgical healthcare systems. With the ongoing need for urgent and emergency colorectal surgery including colorectal cancer surgeries, several questions pertaining to the operating room (OR) utilization and techniques needed to be rapidly addressed. Although patient safety is of paramount importance, caregiver safety is also a critical consideration. During the COVID‐19 pandemic, additional p...

Abstract
Since first reported in 2019, pneumonia associated with 2019 novel coronavirus disease (COVID‐19) has rapidly developed into an outbreak across the world. Number of the patients of all age groups has increased significantly. In order to curb the spread of the epidemic, thousands of health care workers (HCWs) have joined the front line of the fight against this highly contagious disease. When taking care of patients with COVID‐19 pneumonia, HCWs must first protect themselves by per...

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are currently no SARS-CoV-2-specific treatments or vaccines available due to the novelty of the virus. Hence, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here we developed a pilot-scale production of a purified inactivated SARS-CoV-2 virus vaccine candidate (PiCoVacc), which indu...

Coronavirus disease 2019 (COVID-19) was announced a pandemic by WHO on March 11, 2020. As of May 3, 2020, Italy is one of the countries hit hardest by the COVID-19 pandemic, with 28 884 confirmed deaths. In addition to pulmonary insufficiency, COVID-19 is associated with other life-threatening complications such as sepsis, heart failure, and pulmonary embolism. Here we describe patients with COVID-19 who presented with acute limb ischaemia but did not have atherosclerosis, atrial fibrillation...

The COVID-19 epidemic is believed to have started in late January 2020 in France. We report here a case of a patient hospitalized in December 2019 in our intensive care, of our hospital in the north of Paris, for hemoptysis with no etiological diagnosis and for which RT-PCR was performed retrospectively on the stored respiratory sample which confirmed the diagnosis of COVID-19 infection. Based on this result, it appears that the COVID-19 epidemic started much earlier.


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Reverse genetics has been an indispensable tool revolutionising insights into viral pathogenesis and vaccine development. Large RNA virus genomes, such as from Coronaviruses, are cumbersome to clone and manipulate in E. coli due to size and occasional instability1–3. Therefore, an alternative rapid and robust reverse genetics platform for RNA viruses would benefit the research community. Here we show the full functionality of a yeast-based synthetic genomics platform to genetica...

The virus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission via the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), ...

The emergence of the betacoronavirus, SARS-CoV-2, the causative agent of COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in protein folding and immune evasion. Here, using a site-specific mass spectrometric approach, the scie...

Surgical practice guidelines for colorectal cancer must be modified for the unprecedented COVID-19 pandemic as well as potential future outbreaks. Data to support delays in surgical care are limited. This review published in Annals of Surgery analyzes management recommendations and the strength of published evidence using the GRADE system to provide a rational basis for clinical decision-making.

Colorectal cancer surgeries - prioritized as emergency, urgent with (a) imminent emerge...