Posts

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    Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

    16 Dec, 2020
    Abstract
    SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus. It is, however, unknown which features of the serological response may affect clinical outcomes of COVID-19 patients. We analyzed 983 longitudinal plasma samples from 79 hospitalized COVID-19 patients and 175 SARS-CoV-2-infected outpatients and asymptomatic individuals. Within this c...
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    Simultaneous detection and differentiation of SARS-CoV-2, influenza A virus and influenza B virus by one-step quadruplex real-time RT-PCR in patients with clinical manifestations

    15 Dec, 2020
    AbstractObjectives:In order to develop a novel method based on the quadruplex assay which is a valuable diagnostic tool for the diagnosis of SARS-CoV-2 infection, differential diagnosis and detection of coinfections. Methods: A one-step quadruplex real-time reverse transcription-PCR (rRT-PCR) assay was developed for simultaneous detection and differenation of SARS-CoV-2 ORF1ab and N genes, influenza A virus (hIAV) and influenza B virus (hIBV).Results: The results showed tha...
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    Digital Health Surveillance Strategies for Management of Coronavirus Disease 2019

    15 Dec, 2020
    AbstractObjective
    To describe the design, implementation and utilization of Electronic Health Record (EHR) based digital health surveillance strategies used to manage the coronavirus disease (COVID-19) pandemic and ensure delivery of high quality clinical care such as case identification, remote monitoring, telemedicine services, and recruitment to clinical trials at Mayo Clinic.
    Setting
    Mayo Clinic, a large multistate integrated health care system with over 1.5 million annual patien...
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    Focus shifts to antibody cocktails for COVID-19 cytokine storm

    24 Nov, 2020
    Emerging clinical trial data suggest that individual immunomodulatory drugs can dampen the hyperactive immune system in severe COVID-19, but polytherapy is the way forward.
    On June 5 the Ministry of Health of the Russian Federation registered Biocad’s Ilsira (levilimab) as a treatment for severe COVID-19. Ilsira is one of several monoclonal antibodies (mAbs) targeting interleukin-6 receptor (IL-6R) and a host of other inflammatory cytokines currently in clinical testing against coronavirus...
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    Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

    24 Nov, 2020
    Abstract
    Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (...
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    Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis

    10 Nov, 2020
    Background
    Previous studies have indicated Coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate.
    Methods
    We conducted a systematic review of studies that reported fatalities in COVID-19 patients with cancer. A comprehensive meta-analysis that assessed the overall case fatality rate and associated risk factors was performed. Using individual patient data, univariate and multivariate logistic regression analyses were used to estimate odds ratios (OR) for e...
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    Telemedicine Usage Among Urologists During the COVID-19 Pandemic: Cross-Sectional StudyTelemedicine Usage Among Urologists During the COVID-19 Pandemic: Cross-Sectional Study

    10 Nov, 2020
    Abstract
    Background: Prior to the COVID-19 pandemic, urology was one of the specialties with the lowest rates of telemedicine and videoconferencing use. Common barriers to the implementation of telemedicine included a lack of technological literacy, concerns with reimbursement, and resistance to changes in the workplace. In response to the COVID-19 pandemic declared in March 2020, the delivery of urological services globally has quickly shifted to telemedicine to account for the mass ...
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    COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms

    9 Nov, 2020
    Abstract
    Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increa...
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    Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia

    27 Oct, 2020
    Key Points
    Question Does early tocilizumab administration prevent clinical worsening in patients hospitalized with coronavirus disease 2019 (COVID-19) pneumonia?

    Findings In this randomized clinical trial of 126 patients with a partial pressure of arterial oxygen to fraction of inspired oxygen (Pao2/Fio2) ratio between 200 and 300 mm Hg at enrollment, the rate of the primary clinical end point (clinical worsening) was not significantly different between the control group a...
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    How COVID-19 inspired surgical residents to rethink educational programs

    27 Oct, 2020
    The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruptions to education for surgical residents across the country. Residents have experienced reduced operative exposure, decreased time caring for hospitalized patients, and altered rotation schedules. A number of studies have been published since the start of the COVID-19 pandemic regarding the effect of the crisis on residents and resident education across fields including internal medicine, emergency medicine, o...
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    Low dispersion in the infectiousness of COVID-19 cases implies difficulty in control

    20 Oct, 2020
    Abstract
    The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number of secondary cases of a typical index case, is conventionally modelled by a negative-binomial (NB) distribution. Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness, i.e., the dispersion parameter k of the NB distribution, at 0.70 (95% confidence interval: 0.59, 0.98). This suggests that the dispersion in the indi...
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    Safety in endoscopy for patients and healthcare workers during the COVID-19 pandemic

    20 Oct, 2020
    AbstractThe coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is still wreaking havoc in many parts of the world and poses a great burden to healthcare systems worldwide. Mitigation and suppression strategies have been implemented globally but the disease has proven to be difficult to contain. Initially many elective gastrointestinal (GI) endoscopies were cancelled to reduce the risk of infection and conserve personal protective e...