Posts

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    Nosocomial SARS‐CoV‐2 transmission in postoperative infection and mortality: analysis of 14 798 procedures

    10 Oct, 2020
    Abstract
    This study used a national administrative database to estimate perioperative SARS‐CoV‐2 infection risk, and associated mortality, relative to nosocomial transmission rates. The impact of nosocomial transmission was greatest after major emergency surgery, whereas laparoscopic surgery may be protective owing to reduced duration of hospital stay. Procedure‐specific risk estimates are provided to facilitate surgical decision‐making and informed consent.

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    Global impact of the first coronavirus disease 2019 (COVID‐19) pandemic wave on vascular services

    5 Oct, 2020
    Abstract
    This online structured survey has demonstrated the global impact of the COVID‐19 pandemic on vascular services. The majority of centres have documented marked reductions in operating and services provided to vascular patients. In the months during recovery from the resource restrictions imposed during the pandemic peaks, there will be a significant vascular disease burden awaiting surgeons.







    For reading full text click the link
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    Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

    5 Oct, 2020
    Abstract
    Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These au...
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    Covid-19: Risk of death more than doubled in people who also had flu, English data show

    29 Sep, 2020

    People infected with both flu and SARS-CoV-2 are more than twice as likely to die as someone with the new coronavirus alone, emerging evidence from England has shown.

    An analysis by Public Health England (PHE) of cases from January to April 2020 also found that people with the two viruses were more at risk of severe illness. Most cases of coinfection were in older people, and more than half of them died.

    The data, published as a preprint on medRxiv,1 were released ...
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    COVID-19 can affect the heart

    28 Sep, 2020
    COVID-19 has a spectrum of potential heart manifestations with diverse mechanisms
    The family of seven known human coronaviruses are known for their impact on the respiratory tract, not the heart. However, the most recent coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has marked tropism for the heart and can lead to myocarditis (inflammation of the heart), necrosis of its cells, mimicking of a heart attack, arrhythmias, and acute or protracted heart failure (musc...
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    Determinants of the outcomes of patients with cancer infected with SARS-CoV-2: results from the Gustave Roussy cohort

    23 Sep, 2020
    Abstract
    Patients with cancer are presumed to be at increased risk of severe COVID-19 outcomes due to underlying malignancy and treatment-induced immunosuppression. Of the first 178 patients managed for COVID-19 at the Gustave Roussy Cancer Centre, 125 (70.2%) were hospitalized, 47 (26.4%) developed clinical worsening and 31 (17.4%) died. An age of over 70 years, smoking status, metastatic disease, cytotoxic chemotherapy and an Eastern Cooperative Oncology Group score of ≥2 at the last vis...
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    HPB surgery in the time of COVID

    22 Sep, 2020

    Editor

    The pandemic resulting from the transmission of the SARS‐CoV‐2 to the human population has stressed every health care system in the world. The impact on the provision of surgical services has been profound and one of the first and ubiquitous responses was to cease all non‐essential surgical operating. HPB centres internationally have reported a reduction in the number of surgical resections and the adoption of non‐surgical management of pathologies that traditionally were tr...
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    Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

    18 Sep, 2020
    Abstract
    The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we report a humanized monoclonal antibody, H014, that efficiently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at nanomolar concentrations by engaging the spike (S) receptor binding domain (RBD). H0...
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    Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

    18 Sep, 2020
    Abstract
    An excessive immune response during coronavirus disease (COVID-19) can induce cytokine release syndrome (CRS), which is associated with life-threatening complications and disease progression. This retrospective study evaluated the clinical characteristics of severe CRS (sCRS, grade 3–4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). Grade 4 CRS was significantly more common in the COVID-19 group (15/40 (3...
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    Progress in the diagnosis and treatment of COVID-19 and the role of surgeons in the front line of the pandemic

    6 Sep, 2020
    The current struggle to control and contain COVID-19 is critical and surgeons are on the front line in the fight against this virus. Surgeons, and other medical workers in the field of surgery, have a solid foundation and experience in medical treatment and intensive care, and an understanding of the support of respiratory, circulatory, digestive, and other systemic organs. Furthermore, the operative standards of aseptic techniques in their daily work enable surgeons to adapt to the working e...
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    Is BMI Higher in Younger Patients with COVID‐19? Association Between BMI and COVID‐19 Hospitalization by Age

    4 Sep, 2020
    Abstract
    Objective

    Obesity has been found to be a risk factor for hospitalization with coronavirus disease (COVID‐19). This study investigated whether patients hospitalized with COVID‐19 differed in BMI at older versus younger ages and whether trends were independent of diabetes and hypertension.

    Methods

    A cross‐sectional analysis of patients hospitalized with moderate to severe COVID‐19 at Northwestern Memorial Hospital from March 19, 2020, until April 4, 2020, was pe...
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    Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic

    4 Sep, 2020
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global pandemic. It is hypothesized that the virus spreads from person to person via respiratory droplets or contact with contaminated surfaces and objects. Prior studies evaluating environmental contamination with SARS-CoV-2 have been conducted in health care settings treating patients known to have coronavirus disease 2019 (COVID-19); however, studies evaluating clinics that do not ...