Posts
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Elective Surgical Procedure Guidance
25 Aug, 2020Current Status
During the COVID-19 pandemic, surgeries and procedures (collectively referred to as “procedures”) for life-threatening conditions or those with a potential to cause permanent disability have been and continue to be allowed.
Due to the COVID-19 pandemic, hospitals and ambulatory surgical treatment centers (ASTCs) have deferred nonessential procedures to conserve resources for the care of COVID-19 patients. Some procedures that could reasonably be delayed for a time hav... -
Construction of a simple quality appraisal tool for rapid review of laparoscopic surgery guidelines during COVID‐19 pandemic
24 Aug, 2020
Editor
The theoretical danger of virus transmission during Laparoscopic Surgery (LS) via surgical smoke and laparoscopy gas prompted several academic/ national associations to issue many rapidly emerging guidelines for laparoscopic during COVID‐19 pandemic. Conventional appraisal tools like GRADE and AGREE II, which assess the quality of evidence and methodological rigor in the development of guidelines, have very rigorous exhaustive checklists. This makes them impractical for the ... -
What the immune response to the coronavirus says about the prospects for a vaccine
24 Aug, 2020
In the late 1980s, 15 healthy people moved into new apartments in Salisbury, UK. On their third day, each was asked to snort a nostrilful of solution containing a coronavirus — one of several viruses that causes the common cold. Then the volunteers spent three weeks quarantined at the Common Cold Unit, part of the Medical Research Council, where researchers monitored a range of symptoms. Some study participants likened stays at the Common Cold Unit to a vacation — if so, it was a holiday ... -
ESSKA guidelines and recommendations for resuming elective surgery
24 Aug, 2020Abstract
The roadmap to elective surgery resumption after this COVID-19 pandemic should be progressive and cautious. The aim of this paper was to give recommendations and guidelines for resuming elective orthopedic surgery in the safest environment possible. Elective surgery should be performed in COVID-free facilities and hospital stay should be as short as possible. For matters of safety, patients considered first for surgery should be carefully selected according to COVID infection stat... -
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
19 Aug, 2020Abstract
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in vira... -
The conundrum of interleukin-6 blockade in COVID-19
19 Aug, 2020Since the very first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were identified in China, patients with severe manifestations of COVID-19 have been shown to develop a hyperinflammatory syndrome resembling that seen in patients with either macrophage-activation syndrome or cytokine-release syndrome associated with chimeric antigen receptor T-cell therapy. As a result, in the absence of a specific antiviral treatment for SARS-CoV-2 infection, many therapeuti... -
Anti‐SARS‐CoV‐2 Spike Antibodies are Stable in Convalescent Plasma when Stored at 4° Celsius for at Least 6 Weeks
18 Aug, 2020As nations around the world continue to address the public health crisis of Coronavirus Disease 2019 (COVID19), the global medical and scientific communities continue to search for and develop therapeutic strategies for patients. To date, remdesivir presents one such option and can shorten the duration of hospitalization in patients with severe disease. Convalescent plasma (CP) has presented another option, with its use and safety supported by numerous case series and retrospective studies. W... -
Effect of COVID-19 on Surgical Training Across the United States: A National Survey of General Surgery Residents
18 Aug, 2020Introduction
COVID-19 emerged as a global pandemic in 2020 and has affected millions of lives. Surgical training has also been significantly affected by this pandemic, but the exact effect remains unknown. We sought to perform a national survey of general surgery residents in the United States to assess the effect of COVID-19 on surgical resident training, education, and burnout.
Methods
An anonymous online survey was created and distributed to general surgery residents across the Un... -
Joint Statement: Roadmap for Maintaining Essential Surgery during COVID-19 Pandemic
18 Aug, 2020Introduction
In response to the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC), the U.S. Surgeon General and many medical specialties such as the American College of Surgeons and the American Society of Anesthesiologists recommended interim cancelation of elective surgical procedures. Physicians and health care organizations responded appropriately and canceled non-essential cases across the country. Many patients have had their needed surgeries postponed due to th... -
Mutational spectra of SARS‐CoV‐2 orf1ab polyprotein and signature mutations in the United States of America
16 Aug, 2020AbstractPandemic COVID‐19 outbreak has been caused due to SARS‐CoV‐2 pathogen, resulting millions of infection and death worldwide, USA being on top at the present moment. The long, complex orf1ab polyproteins of SARS‐CoV‐2 play an important role in viral RNA synthesis. To assess the impact of mutations in this important domain, we analyzed 1134 complete protein sequences of orf1ab polyprotein from NCBI Virus database from affected patients across various states of USA from December 2019 to 2... -
Development and validation of a surgical prioritization and ranking tool and navigation aid for head and neck cancer (SPARTAN‐HN) in a scarce resource setting: Response to the COVID‐19 pandemic
16 Aug, 2020Abstract
Background
In the wake of the coronavirus disease 2019 (COVID‐19) pandemic, access to surgical care for patients with head and neck cancer (HNC) is limited and unpredictable. Determining which patients should be prioritized is inherently subjective and difficult to assess. The authors have proposed an algorithm to fairly and consistently triage patients and mitigate the risk of adverse outcomes.
Methods
Two separate expert panels, a consensus panel (11 partici... -
Outreach and influence of surgical societies` recommendations on minimally invasive surgery during the COVID-19 pandemic – an anonymized international urologic expert inquiry
16 Aug, 2020Abstract
Objective
To assess the outreach and influence of the main recommendations of surgical governing bodies on adaptation of minimally invasive laparoscopic surgery (MIS) procedures during the COVID-19 pandemic in an anonymized multi-institutional survey.
Materials and Methods
International experts performing MIS were selected on the basis of the contact database of the speakers of the Friends of Israel Urology Symposium. A 24-item questionnaire was built using main recommend...