Science’s COVID-19 reporting is supported by the Pulitzer Center.

In her regular job, Priya Nori runs Montefiore Medical Center’s antibiotic stewardship program, and spends most of her time ensuring that the Bronx-based hospital doesn’t overuse the drugs and allow bacteria resistant to them to thrive. But like many physicians, Nori is now spending all of her time helping treat COVID-19 patients at her New York City hospital, which like other medical centers in the pandemic ...

Introduction
The concept of personal protective equipment (PPE) for the surgeon has been in place for greater than 100 years. The aim has been to protect both the surgeon and the patient. However, as zoonotic respiratory pathogens emerge, surgeons and their teams will need to adapt quickly to what will adequately protect them and their patients. There has been a generalized call for more personal protective equipment (PPE), however, there is a wide array of PPE available. High quality ...

“We know there are things we know we know. We also know there are known unknowns; that is to say that we know there are some things we do not know. But there are also unknown unknowns—the ones we don’t know we don’t know.”
– Donald Rumsfeld, February 12, 2002




The history of informed consent is one of continuous evolution in search of a best practice, from the mid-20th century, physi...

We report the neurologic features in an observational series of 58 of 64 consecutive patients admitted to the hospital because of acute respiratory distress syndrome (ARDS) due to Covid-19. The patients received similar evaluations by intensivists in two intensive care units (ICUs) in Strasbourg, France, between March 3 and April 3, 2020.




Six patients were excluded because of paralytic neuromuscular blockade when neurologic...

IntroductionIn December 2019, a novel coronavirus was identified as the pathogen to cause pneumonia in Wuhan, China , which was temporarily named as 2019-nCoV by WHO. On 11 February 2020, based on the phylogeny, taxonomy and established practice, 2019-nCoV was officially named as SARS-CoV-2, and the disease caused by SARS-CoV-2 was named as COVID-19. SARS-CoV-2 can be transmitted from person to person through respiratory droplets and close contact , posing a huge public health challenge...

NIHR Global Health Research Unit on Global Surgery created CovidSurg, an international collaborating group of surgeons and anesthetists with representation from 20 different countries: Canada, China, Germany, Hong Kong, Italy, Korea, Singapore, Spain, United Kingdom, United States, Benin, Democratic Republic of Congo, Ghana, India, Mexico, Nigeria, Rwanda, Sierra Leone, South Africa and Zimbabwe. This platform of studies aims to explore the impact of Covid-19 in surgical patients and services...

Early and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is key to the management of the coronavirus disease 2019 (COVID-19) pandemic. Following its emergence in China in December, 2019, SARS-CoV-2 has spread in the northern hemisphere during the winter season, when other respiratory viruses, including influenza, co-circulate. This epidemiological conjunction complicates clinical diagnosis of COVID-19 because patients often present with influe...

BACKGROUND
Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2.



METHODS
We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients rece...

Aerosols and droplets generated during speech have been implicated in the person-to-person transmission of viruses, and there is current interest in understanding the mechanisms responsible for the spread of Covid-19 by these means. The act of speaking generates oral fluid droplets that vary widely in size, and these droplets can harbor infectious virus particles. Whereas large droplets fall quickly to the ground, small droplets can dehydrate and linger as “droplet nuclei” in the air, ...

A text message from a colleague in mainland China flashed across the screen of one of our cell phones on New Year’s Eve, 2019, notifying us of an emerging cluster of cases of atypical pneumonia in Wuhan. Amid flashbacks to the fearsome severe acute respiratory syndrome (SARS) epidemic in 2002–2003, we immediately reached out to our network of collaborators for further leads. An uncomfortable silence followed over the next few weeks.




By mid-January, we noticed the first ...

Several research lines are currently ongoing to address the multitude of facets of the pandemic COVID-19. In line with the One-Health concept, extending the target of the studies to the animals which humans are continuously interacting with may favor a better understanding of the SARS-CoV-2 biology and pathogenetic mechanisms; thus, helping to adopt the most suitable containment measures. The last two decades have already faced severe manifestations of the coronavirus infection in both humans...

Objectives:

To improve the infection control and prevention practices against coronavirus disease 2019 (COVID-19) in radiology department through loophole identification and providing rectifying measurements.

Methods:

Retrospective analysis of 2 cases of health-care-associated COVID-19 transmission in 2 radiology departments and comparing the infection control and prevention practices against COVID-19 with the practices of our department, where no COVID-19 transmissio...