AbstractThe world is going through a life-threating, a war-like, virus attack called COVID-19. Since its inception in the last four months, it has been increased ten times every two weeks outside mainland China. In this case, we address this challenging human crisis with a focus on the early discovery of coronavirus asymptomatic patients which would help to reduce the cross-infection of COVID-19 that estimates to attack at least 60% of the world population, according to WHO (2020). This p...

A novel SARS-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans1,2. A key to tackling this epidemic is to understand the virus’s receptor recognition mechanism, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor - human ACE2 (hACE2)3,4. Here we determined the crystal structure of the SARS-CoV-2 receptor-binding domain (RBD) (engineered to facilitate crystallization) in complex with hACE2. Compared wi...

Human infections with a novel coronavirus (SARS-CoV-2) were first identified via syndromic surveillance in December of 2019 in Wuhan China. Since identification, infections (coronavirus disease-2019; COVID-19) caused by this novel pathogen have spread globally, with more than 250,000 confirmed cases as of March 21, 2020. An open-label clinical trial has just concluded, suggesting improved resolution of viremia with use of two existing therapies: hydroxychloroquine (HCQ) as monotherapy, and in...

Estimating the number of infections and the impact of nonpharmaceutical interventions on COVID-19 in 11 European countriesSummary  - Click to access full textFollowing the emergence of a novel coronavirus (SARS-CoV-2) and its spread outside of China, Europe is now experiencing large epidemics. In response, many European countries have implemented unprecedented non-pharmaceutical interventions including case isolation, the closure of schools and universities, banning of ma...

AbstractFew novel or emerging infectious diseases have posed such vital ethical challenges so quickly and dramatically as the novel coronavirus SARS‐CoV‐2. The World Health Organization declared a public health emergency of international concern and recently classified COVID‐19 as a worldwide pandemic. As of this writing, the epidemic has not yet peaked in the United States, but community transmission is widespread. President Trump declared a national emergency as fifty governors declared sta...

An artificial intelligence tool accurately predicted which patients newly infected with the COVID-19 virus would go on to develop severe respiratory disease, a new study found.


Towards an Artificial Intelligence Framework for Data-Driven Prediction of Coronavirus Clinical Severity
AbstractThe virus SARS-CoV2, which causes coronavirus disease (COVID-19) has become a pandemic and has spread to every inhabited continent. Given the increasing caseload, there is an urgent need to aug...

As of March 25, 2020, 414 179 cases and 18 440 deaths due to coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had been reported worldwide. The epidemic began in mainland China, with a geographical focus in the city of Wuhan, Hubei. However, on Feb 26, 2020, the rate of increase in cases became greater in the rest of the world than inside China. Substantial outbreaks are occurring in Italy (69 176 cases), the USA (51 91...

The infection-control measures put in place in many European countries – such as national lockdowns – are reducing the spread of the coronavirus. Across 11 countries in Western and Northern Europe, between 21,000 and 120,000 deaths will probably have been avoided by the end of March, according to a new model by a group at Imperial College London. The study, published by the Imperial College COVID-19 Response Team on 30 March, estimates the effects that non-pharmaceutical interventio...

Pregnant women infected with Covid-19 were evaluated to provide future help for clinical prevention and treatment. All the cases were from Hospital of Hubei Province and had the gestational week from 38th weeks to 41th weeks. Their primary initial manifestations were merely low-grade postpartum fever or mild respiratory symptoms. 




As a conclusion, these doctors stated that the protective measures are necessary on admission, and the instant CT scan and ...

The coronavirus disease 2019 (COVID-19) epidemic spread within China, and secondarily also outside China, with a basic reproductive number estimated to be from to and a mortality rate of around 2-3%. In the EU (and European Economic Area) and the UK, as of March 6, 2020, 5544 cases have been reported (423 in France), including 159 deaths (seven in France).
So far, several studies have described demographic, clinical, and biological characteristics of patients with COVID-19, ...

Since the outbreak of coronavirus disease 2019 (COVID-19) first began in Wuhan, China, in December, 2019, the viral epidemic has quickly engulfed China. Here we describe a case of a patient with chronic lymphocytic leukaemia with COVID-19.

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In conclusion, clinical and biochemical data of COVID-19 might be partly masked by coexisting chronic lymphocytic leukaemia; better diagnostic strategies (ie, superior CT differential techniques such as radiomics) could be used f...

Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort studyA cohort study of 44 672 Chinese cases reported that 2·1% of patients were younger than 20 years, and 1·2% were asymptomatic. Pneumonia is the leading cause of mortality in children.8 Distinct immunological responses to viral infections can exist in children and result in severe damage to vital organsTo read full text ...